Method for coating bladder and urethral mucosal surface



United States Patent 3,239,414 METHUH) FOR COATENG BLADDER AND URETHRAL MUCQSAL SURFACE Robert L. Rowan and Yetta Rowan, both of 141 E. 33rd St., New York, NY. No Drawing. Filed Dec. 26, 1962., Ser. No. 247,286 3 Claims. (Cl. 16750) This invention relates to a method for treating urological disorders by means of a therapeutic composition and more particularly by means of a silicone compos tion used to coat the interior walls of the human bladder and urethra.

It is a general object of this invention to provide a method for relieving an inflammation of the human bladder.

It is a more specific object of this invention to provide a method whereby the walls of the human bladder and urethra are coated with a stable and chemically inert liquid and are thereby insulated from ambient internal irritating body fluids such as urine.

Still another object of this invention is to provide a new chemical for use in the treatment of bladder disorders based on a new and different mechanism of action as well as a previously unused drug in the human bladder.

Other objects of this invention will become apparent to those skilled in the art in the light of the following description.

In accordance with this invention the claimed method uses as a therapeutic composition a liquid having as an ingredient an organo-silicon oxide polymer (or organopolysiloxane). These liquids are also popularly called silicones.

It is known that organopolysiloxanes are generally insoluble liquids. In order for a liquid to be adapted for internal use such as a coating agent for the human bladder the liquid must, however, have several other chemical, physical and physiological properties. For instance, such a liquid should have great thermal and oxida- .tive stability. The liquid should be chemically inert with the human body fluids. It should have a low volatility.

It has been found that certain non-toxic organopolysiloxane liquids, and in particular dimethylpolysiloxane liquids, have all of the aforementioned desirable properties. The aforementioned liquids are generally clear and colorless. They can be sterilized repeatedly without significantly changing their physical or chemical properties. Furthermore studies have shown that the aforementioned liquids are, when applied within certain limits to the human bladder, completely non-toxic.

The general chemical formula of organopolysiloxanes can be represented as follows:

Where R is a CH or other organic radical and 11:0 to 2000.

The chemical formula of the dimethylpolysiloxane liquid can be generally represented as follows:

$113 $113 (3H3 CH3SlO-SiOSiCHa I L: CH3 CH3 1} CH3 wherein the length n of the polymer chain determines the viscosity of the liquid.

An inflammation in the human bladder or urethra is difficult to treat because the bladder or urethra can not be put to rest as for instance the immobilizing of an injute-d extremity of a patient. It is therefore necessary to treat such an inflammation differently in order to avoid 3,239,414 Patented Mar. 8, 1966 "ice the constant irritation of the walls of the bladder and/ or urethra by the urinary output of the body. Illustrative of such a condition is a patient suffering from idiopathic cystitis. In the latter case the urine of the patient carries causative material which not only irritates but increases the disease process. Similarly if the cause of the disease is inherent in the bladder wall, the exposure to the urine acts as an irritant. It has been found that when introducing the dimethylpolysiloxane fluid into the bladder and urethra the fluid effectively coats the walls of the bladder and thereby acts as a barrier between the inflamed mucosa walls and the urine.

The coating action of the dimethylpolysiloxane liquid is so effective because of its relatively low surface tension. For instance, in a viscosity range of 10 centistokes to 1000 centistokes the surface tension of the dimethylpolysiloxane liquid has an approximate corresponding range of about 20 dynes/ centimeter to about 21.5 dynes/ centimeter. When comparing this with the surface tension of water which is about 72 dynes/ centimeter it becomes apparent why this fluid has such a high surface activity and consequently is such an effective coating agent.

It has been found that the dimethylpolysiloxane liquid is particularly effective in relieving the undesirable symptoms of cystitis such as urinary frequency, bearing down sensations, burning on urination, etc. by protecting the mucosa walls from the irritative effects of the urine. This protective coating action is particularly effective in treating cases of cystitis and in cases following X-ray therapy to the bladder for cancer. It should be noted however that the silicone liquid is only meant to be used for relief of symptology and no claim is made that the claims set forth hereinafter define a method for treating the etiology of any of the aforementioned symptoms.

An example of treating a patient by the aforedescribed method is hereinafter given by way of illustration but not by way of limiting the claims set forth below to this example alone.

Sterile disposable equipment is used in order to preclude the need for washing the silicone fluid from the equipment after its use. The equipment therefore is meant to be discarded after using it only once. The patient is prepared for catherization by the usual known sterile technique. A sterile disposable urethral catheter with introducer is used to empty the bladder of urine. About ten cubic centimeters of the silicone liquid are then instilled via a disposable syringe through the catheter into the bladder. The catheter is then removed. It has been found that dimethylpolysiloxane liquid having a viscosity range from 350 to 1000 centistokes is best suited for the method of treatment forming part of this invention.

Although a preferred example of the invention has been described, it will be understood that modifications may be made within the spirit and scope of the appended claims.

We now claim:

1. A method for coating irritated bladder and urethral mucosal surfaces, which comprises the steps of removing the urine from the bladder, and of introducing about 10 to 40 cubic centimeters of dimethylpolysiloxane liquid into the bladder of a patient via the urethra, thereby coating the walls of said bladder with said liquid.

2. A method for coating irritated bladder and urethral mucosal surfaces, which comprises the steps of removing the urine in the bladder of a patient by means of a catheter, and introducing about 10 to 40 cubic centimeters of a non-toxic dimethylpolysiloxane liquid into said bladder via said catheter, thereby coating the mucosal walls of the bladder of said patient with said dimethylpolysiloxane liquid.

S 3. A method for coating irritated bladder and urethral mucosal surfaces, which comprises the steps of removing the urine in the bladder of a patient by means of a catheter,vand introducing about 10 to 40 cubic centimeters of a non-toxic dirnethylpolysiloxane liquid, having a vis- Cosity within the range of 350 to 1000 centistokes, into said bladder via said catheter, thereby coating the mucosal walls of the bladder of said patienttwith said-dimethylpolysiloxane liquid.

7 References Cited by the Examiner UNITED STATES PATENTS 2,721,825 10/1955 Hardie 16765' 8/1960 Feinstone 167,65 i

FOREIGN PATENTS 7 803,289 10/1958 Great Britain;

' OTHER REFERENCES-- 5 Barondes etalJ: The Military Surgeonf. 106' (5), May 2 1950, pp.v379--387.

Lesser; Drug & Cosmetic Industry, 72 (5) May 1953, pp. 616, 617, 688-692. V a V V McGregor: Silicones inMe'dicineand Surgery, 1957, 1 Dow Corning Corp Midland, Michigan, 44 pages, esp.; pp. 27-29,. I V V Talbot: J. Invest. Derm., September 1951, pp.' 125-6.

FRANK CACCIAPAGLIA; JR; Primary Examiner. 

1. A METHOD FOR COATING IRRITATED BLADDER AND URETHRAL MUSCOSAL SURFACES, WHICH COMPRISES THE STEPS OF REMOVING THE URINE FROM THE BLADDER, AND OF INTRODUCING ABOUT 10 TO 40 CUBIC CENTIMETERS OF DIMETHYLPOLYSILOXANE LIQUID INTO THE BLADDER OF A PATIENT VIA THE URETHRA, THEREBY COATING THE WALLS OF SAID BLADDER WITH SAID LIQUID. 